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Analysis and Purification Methods in Combinatorial Chemistry

 


Analysis and Purification Methods in Combinatorial Chemistry is edited by Bing Yan and published by Wiley Intersciences in 2004 is a PDF book for free download.

Quality measurement, control, and improvement in combinatorial chemistry

Combinatorial chemistry has developed rapidly in the past decade, with great advances made by scientists working on analysis and purification of a large number of compounds and the analysis of polymer-bound compounds. 

However, formidable challenges lie ahead of today's researcher. For example, high-throughput analysis and purification technologies must be further developed to ensure combinatorial libraries are "purifiable," and "drugable."

To this end, Analysis and Purification Methods in Combinatorial Chemistry describes various analytical techniques and systems for the development, validation, quality control, purification, and physicochemical testing of combinatorial libraries. 

A new volume in Wiley's Chemical Analysis series, this text has four parts covering:

* Various approaches to monitoring reactions on solid support and optimizing reactions for library synthesis

* High-throughput analytical methods used to analyze the quality of libraries

* High-throughput purification techniques

* Analytical methods applied in post-synthesis and post-purification stages

Drawing from the contributions of respected experts in combinatorial chemistry, this comprehensive book provides coverage of applications of Nuclear Magnetic Resonance (NMR), liquid chromatography/mass spectrometry (LC/MS), Fourier Transform Infrared (FTIR), micellar electrokinetic chromatography (MEKC) technologies, as well as other analytical techniques.

This eminently useful volume is an essential addition to the library of students and researchers studying or working in analytical chemistry, combinatorial chemistry, medicinal chemistry, organic chemistry, biotechnology, biochemistry, or biophysics.

About the Author:

BING YAN, PhD, was born in China and received his PhD inchemistry at Columbia University in 1990. He then worked at CambridgeUniversity and the University of Texas-Houston Medical School as a postdoctoralfellow. 

From 1993 to 1999, he worked for Novartis in the Core Technologies areaof preclinical research in New Jersey. He is currently at the DiscoveryChemistry division of Discovery Partners International, Inc., in San Francisco.

His major research interests are drug discovery, optimization of solid-phaseand solution-phase combinatorial synthesis, high-throughput quantitative andqualitative analysis, and high-throughput purification of combinatoriallibraries. He has written four books and published over seventy reviews andresearch articles.

Contents:

Analysis for feasibility and optimization of library synthesis

Quantitative analysis in organic synthesis with NMR spectroscopy

19F gel-phase NMR spectroscopy for reaction monitoring and quantification of resin loading

The application of single-bead FTIR and color test for reaction monitoring and building block validation in combinatorial library synthesis

HR-MS NMR analysis of compounds attached to polymer supports

Multivariate tools for real-time monitoring and optimization of combinatorial materials and process conditions

Mass spectrometry and soluble polymeric support

High-throughput analysis for library quality control

High-throughput  NMR techniques for combinatorial chemical library analysis

Micellar electrokinetic chromatography as a tool for combinatorial chemistry analysis: theory and applications

Characterization of split-pool encoded combinatorial libraries

High-throughput purification to improve library quality

Strategies and methods for purifying organic compounds and combinatorial libraries

High-throughput purification: triage and optimization

Parallel HPLC in high-throughput analysis and purification

Analysis for compounds stability and durgability

Organic compounds stability in large, diverse pharmaceutical screening collection

Quartz crystal microbalance in biomolecular recognition

High-throughput physicochemical profiling: potential and limitations

Solubility in the designs of combinatorial libraries

High-throughput determination of log D values by LC/MS method

About the book:

Publisher ‏ : ‎ Wiley-Interscience; 1st edition (May 2, 2008)

Publication date ‏ : ‎ May 2, 2008

Language ‏ : ‎ English

Print length ‏ : ‎ 481 pages

File : ‎ PDF, 7205 KB

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