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Heterocyclic Chemistry Joule in pdf


Download this PDF book:  Heterocyclic Chemistry 1st Edition by John A. Joule, Keith Mills 

Free download Heterocyclic Chemistry (5th edition) authored by John A. Joule and Keith Mills in pdf.

Heterocyclic compounds have a wide range of applications but are of particular interest in medicinal chemistry, and this has catalysed the discovery and development of much heterocyclic chemistry and methods.

The preparation of a fifth edition has allowed us to review thoroughly the material included in the earlier editions, to make amendments in the light of new knowledge, and to include recent work. 

Within the restrictions that space dictates, we believe that all of the most significant heterocyclic chemistry of the 20th century and important more recent developments, has been covered or referenced.

We have maintained the principal aim of the earlier editions – to teach the fundamentals of heterocyclic reactivity and synthesis in a way that is understandable by undergraduate students. 

However, in recognition of the level at which much heterocyclic chemistry is now normally taught, we include more advanced and current material, which makes the book appropriate both for post – graduate level courses, and as a reference text for those involved in heterocyclic chemistry in the work place.

New in this edition is the use of colour in the schemes. We have highlighted in red those parts of products (or intermediates) where a change in structure or bonding has taken place. 

We hope that this both facilitates comprehension and understanding of the chemical changes that are occurring and, especially for the undergraduate student, quickly focuses attention on just those parts of the molecules where structural change has occurred.

For example, in the first reaction below, only changes at the pyridine nitrogen are involved; in the second example, the introduced bromine resulting from the substitution and its new bond to the heterocycle, are highlighted. We also show all positive and negative charges in red.


Heterocyclic Nomenclature

Structures and Spectroscopic Properties of Aromatic Heterocycles

Substitutions of Aromatic Heterocycles

Organometallic Heterocyclic Chemistry

Methods in Heterocyclic Chemistry

Typical Reactivity of Pyridines, Quinolines and Isoquinolines

Pyridines: Reactions and Synthesis

Quinolines and Isoquinolines: Reactions and Synthesis

Typical Reactivity of Pyrylium and Benzopyrylium Ions, Pyrones and Benzopyrones

Pyryliums, 2- and 4-Pyrones: Reactions and Synthesis

Benzopyryliums and Benzopyrones: Reactions and Synthesis

Typical Reactivity of the Diazine: Pyridazine, Pyrimidine and Pyrazine

The Diazines: Pyridazine, Pyrimidine, and Pyrazine: Reactions and Synthesis

Typical Reactivity of Pyrroles, Furans and Thiophenes

Pyrroles: Reactions and Synthesis

Thiophenes: Reactions and Synthesis

Furans: Reactions and Synthesis

Typical Reactivity of Indoles, Benzo[b]thiophenes, Benzo[b]furans, Isoindoles, Benzo[c]thiophenes and Isobenzofurans

Indoles: Reactions and Synthesis

Benzo[b]thiophenes and Benzo[b]furans: Reactions and Synthesis

Isoindoles, Benzo[c]thiophenes and Isobenzofurans: Reactions and Synthesis

Typical Reactivity of 1,3- and 1,2-Azoles and Benzo-1,3- and -1,2-Azoles

1,3-Azoles: Imidazoles, Thiazoles and Oxazoles: Reactions and Synthesis

1,2-Azoles: Pyrazoles, Isothiazoles, Isoxazoles: Reactions and Synthesis

Benzanellated Azoles: Reactions and Synthesis

Purines: Reactions and Synthesis

Heterocycles Containing a Ring-Junction Nitrogen (Bridgehead Compounds)

Heterocycles Containing More Than Two Heteroatoms

Saturated and Partially Unsaturated Heterocyclic Compounds: Reactions and Synthesis

Special Topics

Heterocycles in Biochemistry; Heterocyclic Natural Products

Heterocycles in Medicine

About the Author

John Joule is Emeritus Professor in the School of Chemistry, The University of Manchester, UK

Keith Mills spent 25 years in the Medicinal Chemistry and Development Chemistry departments at GlaxoSmithKline, Stevenage, UK, and is now an independent consultant.

About the book:

Publisher ‏ : ‎ Wiley-Blackwell; 1st edition (June 1, 2010)

Language ‏ : ‎ English

Pages ‏ : ‎ 720 

File : PDF, 26MB


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