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Advanced Organic Chemistry in pdf


Download This PDF Book: Advanced Organic Chemistry: Part B: Reaction and Synthesis by Carey, Francis A. Published by Springer 5th 2008, for free.


The focus of Part B is on the closely interrelated topics of reactions and synthesis. In each of the first twelve chapters, we consider a group of related reactions that have been chosen for discussion primarily on the basis of their usefulness in synthesis. 

For each reaction we present an outline of the mechanism, its regio- and stereochemical characteristics, and information on typical reaction conditions. 

For the more commonly used reactions, the schemes contain several examples, which may include examples of the reaction in relatively simple molecules and in more complex structures. 

The goal of these chapters is to develop a fundamental base of knowledge about organic reactions in the context of synthesis. We want to be able to answer questions such as: What transformation does a reaction achieve? 

What is the mechanism of the reaction? What reagents and reaction conditions are typically used? What substances can catalyze the reaction? How sensitive is the reaction to other functional groups and the steric environment? What factors control the stereoselectivity of the reaction? Under what conditions is the reaction enantioselective?

Synthesis is the application of one or more reactions to the preparation of a particular target compound, and can pertain to a single-step transformation or to a number of sequential steps. The selection of a reaction or series of reactions for a synthesis involves making a judgment about the most effective possibility among the available options. 

There may be a number of possibilities for the synthesis of a particular compound. For example, in the course of learning about the reactions in Chapter 1 to 12, we will encounter a number of ways of making ketones, as outlined in the scheme that follows


Chapter 1. Alkylation of Enolates and Other Carbon Nucleophiles

Chapter 2. Reactions of Carbon Nucleophiles with Carbonyl Compounds

Chapter 3. Functional Group Interconversion by Substitution, Including Protection and Deprotection 

Chapter 4. Electrophilic Additions to Carbon-Carbon Multiple Bonds

Chapter 5. Reduction of Carbon-Carbon Multiple Bonds, Carbonyl Groups, and Other Functional Groups 

Chapter 6. Concerted Cycloadditions, Unimolecular Rearrangements, and Thermal Eliminations 

Chapter 7. Organometallic Compounds of Group I and II Metals

Chapter 8. Reactions Involving Transition Metals

Chapter 9. Carbon-Carbon Bond-Forming Reactions of Compounds of Boron, Silicon, and Tin

Chapter 10. Reactions Involving Carbocations, Carbenes, and Radicals as Reactive Intermediates

Chapter 11. Aromatic Substitution Reactions 

Chapter 12. Oxidations

Chapter 13. Multistep Syntheses

About The Book:

Publisher ‏ : ‎Springer, 5th edition (2008)

Language ‏ : ‎ English

Pages ‏ : ‎ 1347 

File : PDF, 18 MB


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